Scaffolds loaded with low-dose recombinant bone morphogenic protein-2 is comparable to autograft bone as a bone graft substitute for anterior lumbar interbody fusion in a large animal model, according to a study published in Spine.
Researchers performed anterior lumbar interbody fusion in 11 Yorkshire pigs with either medical grade poly-20 percent tricalcium phosphate, autologous bone grafts, mPCL/TCP and bone marrow-derived multipotent stromal cells or a combination of mPCL/TCP and 0.6 mg of rhBMP-2.
The group with BMSCs lagged behind autograft bone and rhBMP-2, although there was evidence of bone growth that could constitute additional research. There was no implant rejection, chronic inflammation or other complications.
The authors suggested mPCL/TCP scaffolds loaded with rhBMP-2 or BMSCs could be a good alternative to conventional cages and autograft bone.
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The group with BMSCs lagged behind autograft bone and rhBMP-2, although there was evidence of bone growth that could constitute additional research. There was no implant rejection, chronic inflammation or other complications.
The authors suggested mPCL/TCP scaffolds loaded with rhBMP-2 or BMSCs could be a good alternative to conventional cages and autograft bone.
Related Articles on BMP:
Study: BMP Use Increases Complication Risk Only in Anterior Cervical Fusion
Study: 85% of BMP Procedures Between 2002 and 2007 Used for Off-Label Applications
NASS: BMP Use in Spinal Fusions May Cause Male Infertility