The U.S. Department of Justice announced it would end its four year investigation related to off-label use of Medtronic's Infuse for spinal fusions.

AxioMed Spine Corp. has announced it has received the CE mark approval for its Freedom cervical disc, according to a news release.

Mazor Robotics, an Israel-based robotic spinal system company and developer of the Renaissance system, reported $2.4 million in revenue for the first quarter of 2012, an increase over the same period last year.

The Food and Drug Administration granted 14 spine device-related clearances in April, according to an FDA report.

TranS1, a Wilmington, N.C.-based spine device company, reported a 26 percent decrease in revenue for the first quarter of 2012.

Alphatec Spine reported first quarter revenue of $48.5 million, slightly less than the same period last year.

Here are 20 orthopedic and spine device company leadership moves so far this year.

The Food and Drug Administration granted 33 orthopedic- and spine-related device clearances in April.

Jupiter, Fla.-based company BioRestorative Therapies has announced improvements in the latest version of its stem cell disc delivery device, which is used for treating bulging and herniated discs.

Surgical device company Misonix has signed an exclusive distribution agreement with Neuro Dynamics for distribution of the company's SonaStar Ultrasonic Surgical Aspirator and the BoneScalpel Ultrasonic Bone Cutter.